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Did you know that some medications you take could put you at a higher risk of developing skin cancer? It’s important to understand how these medicines, especially immunosuppressants, can affect your skin health.
Understanding the Connection Between Medications and Skin Cancer
Our immune system plays a crucial role in keeping us healthy, including protecting us against cancer. But certain medications, especially immunosuppressants, weaken the immune system. A weaker immune system can make it harder for our bodies to fight off cancer cells naturally, thereby increasing the risk of developing skin cancer.
Medications That Increase Skin Cancer Risk
Some common medications that can heighten your risk of skin cancer include corticosteroids (such as prednisone), certain biologics (such as Enbrel, Remicade, and Humira), and immunosuppressants prescribed for conditions like organ transplants, autoimmune diseases, and severe skin conditions. Among the widely recognized immunosuppressants known to heighten the risk of skin cancer are medications such as tacrolimus (Prograf), azathioprine (Imuran), mycophenolate (Cellcept), cyclosporine, methotrexate, rituximab, and JAK inhibitors like Xeljanz and Rinvoq.1 Even common blood pressure medications, such as hydrochlorothiazide (HCTZ), can increase your risk of skin cancer!2
While these medications help manage many different medical conditions, they can also make you more vulnerable to skin cancer. This skin cancer risk is compounded by the plentiful UV light that is present year-round in Colorado.
The Importance of Annual Total Body Skin Exams
If you’re on immunosuppressants or any medication that increases skin cancer risk, it’s crucial to see a dermatologist regularly. Dermatologists are experts in detecting skin cancer early, which greatly improves treatment outcomes. By scheduling annual total body skin exams, you can catch any potential issues before they become more serious. Sometimes dermatologists can even prescribe supplements/medications to reduce your risk of skin cancer. Your dermatologist can assist you in establishing the optimal frequency for skin cancer screenings tailored to your specific risk factors.
Dr. Ryan Lawrence’s Tips for Sun Protection
Protecting your skin from the sun’s harmful rays is essential, especially if you’re on medications that increase skin cancer risk.
Remember to:
- Wear sunscreen with an SPF of at least 30 every day, even on cloudy days. Don’t forget to reapply!
- Cover up with clothing, hats, and sunglasses when you’re outside.
- Seek shade, especially during peak sun hours between 10 AM and 4 PM.
- Avoid indoor tanning beds, which also increase your risk of skin cancer.
Schedule an Appointment with a Trusted Vanguard Provider
Taking certain medications, especially immunosuppressants, can increase your risk of skin cancer. But by being proactive and seeing a dermatologist regularly for skin exams, you can protect yourself and catch any issues early. Remember to prioritize your skin health, especially if you’re on medications that affect your immune system. Your skin deserves the best care possible!
If you would like to speak with one of our trusted dermatology providers, contact us today at 719-355-1585 or fill out our online appointment request form.
Citations:
- Kreher MA, Noland MMB, Konda S, Longo MI, Valdes-Rodriguez R. Risk of melanoma and nonmelanoma skin cancer with immunosuppressants, part I: Calcineurin inhibitors, thiopurines, IMDH inhibitors, mTOR inhibitors, and corticosteroids. J Am Acad Dermatol. 2023;88(3):521-530.
- Shao SC, Lai CC, Chen YH, Lai ECC, Hung MJ, Chi CC. Associations of thiazide use with skin cancers: a systematic review and meta-analysis. BMC Med. 2022;20(1):228.
Ryan Lawrence, MD is a board-certified dermatologist at Vanguard Skin Specialists. He practices general and surgical dermatology at our Pueblo and Broadmoor office. He has special interest in treating skin cancer, psoriasis, eczema, and many other medical and surgical dermatologic conditions.
